Both brothers are controlled by one player, and move and shoot at the same time. They also have a unique UI to accommodate them, with Esau's health, active item, and trinket all in the bottom corner that normally shows your pill/card/rune. At first it's essentially like having double firepower, but it starts to get funky once the brothers have different movement speeds, tear effects, or even things like flight.

Mechanically Unusual Class: The player is in control of two characters at once, and needs to manage their health and who gets what items.

The Dividual: Both Jacob and Esau are controlled by the player and if one dies both die.

Damn You, Muscle Memory!: The twins automatically use any pick-ups as Esau's 'use item' button is 'Q', the standard use pick-up item button.

Can't Live Without You: If one of the brothers dies, both die, so neglecting one of them to make the other stronger is out of the question.

Born Unlucky: Esau starts with negative luck.

Amazing Technicolor Population: Esau is a dark red because the Biblical Esau was described as 'red all over' when he was born.Thankfully, the developers realized this and made it so that Suicide King never spawns in a Jacob & Esau run. Anti-Frustration Features: Since they automatically use any cards and pills they pick up, picking up a red card would run the risk of that card being Suicide King.Jacob looks like normal person while Esau has dark red skin, but both have the same hair style. They are named after the twin sons of Isaac. Both brothers are controlled simultaneously, but they have separate items, trinkets, and health bars with Jacob having more health and Esau having more damage. Black flames can inflict fear with their shots, while white flames can regenerate themselves and other flames and their shots can block enemy tears.Дebut: AntibirthA pair of brothers that are unlocked by defeating The Witness for the first time. Secret Art: Bethany is the only character capable of spawning white and black flames with Book of Virtues, by consuming Immortal and black hearts from her counter.Nonstandard Character Design: Bethany is the only playable character with a pair of eyelashes.Any item that remove all of her hearts will kill her for example Abaddon remove all of her red hearts and add the Black Hearts to the counter. This lets her use space bar items more often at the cost of being more dependent on health increasing items and pick-ups. Mechanically Unusual Fighter: As stated above, Bethany uses heart pick-ups to increase the counter to recharge space bar items.However, the soul hearts function to get much more use out of her starting item, and with enough cleared rooms and/or soul hearts picked up, she could have a huge multi-layered tornado of flames that each fires a spectral shot on its own. Magikarp Power: Bethany's inability to pick up soul hearts means that one would have less health over all, and needs to avoid taking damage period to have a good chance at getting an Angel/Devil room for the floor, to say nothing of the fancy dodging required to build up flames with Book of Virtues.Girlish Pigtails: She sports a pair tied up with blue ribbons.Aerith and Bob: The only playable character with a name taken from a town instead of a character.She can spend these hearts to use her active item if it isn't charged. Uniquely, she cannot use soul, black, or immortal hearts, instead adding them to a consumable counter when picked up.

She starts with the Book Of Virtues, which summons Wisp familiars that shoot alongside her and block shots, but can be destroyed. Debut: AntibirthNamed after the village that was home to Lazarus, Bethany is unlocked by having any combination of 12 soul, black, or immortal hearts during a run.

Binding of isaac antibirth unlocks